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Frogeye leaf spot disease on flue-cured tobacco is caused by the fungal pathogen, Cercospora nicotianae. This disease has historically been an issue for ripe tobacco, but has become more common over the last couple of years. The disease is found most commonly on lower, more mature leaves of the plant, but can also affect green tissues. Infections are not often severe enough to impact yield, but, under conducive environmental conditions, can cause severe damage to leaves.